When you think of supporting your immune system, you may think of consuming fresh foods, getting adequate sleep, or taking oral supplements like vitamin C, zinc, or probiotics. But did you know that you can quickly stimulate your immune system by targeting the immune tissue in your mouth? The soft tissue in your mouth that composes the inside of your lips and cheeks is known as buccal tissue and is a vital component of overall immunity! In fact, buccal tissue is capable of sending rapid signals to other parts of the immune system in a matter of minutes.

Compared to the deeper, more internal tissues, our mouths more frequently encounter the barrage of microbes present in the outside world. Luckily, our oral immune system is quick to respond and well-equipped to fend off foreign invaders. Saliva and buccal tissue are rich in immune cells, such as T lymphocytes and immunoglobulins, that remove pathogens before they have a chance to further invade our bodies.1 This oral immune system also sends messages to numerous other tissues in the body, preparing our internal defenses before the pathogen even arrives at these distant sites. This gives us an enormous head start in fighting infection!

In addition, the buccal mucosa contains special gateways, also known as microfold (M) cells, which allow certain molecules to enter the bloodstream, while simultaneously guarding against pathogens.2 While other mucosal sites in the gut, lungs, and urogenital areas also contain M cells, the buccal tissue is the most permeable. This means that it rapidly absorbs beneficial compounds like probiotics, herbs, and some nutrients.

MegaCidin™ is a robust, next-generation throat spray that contains a unique and potent combination of ingredients clinically proven to support overall immunity. MegaCidin™ harnesses the power of probiotic spores along with the highly effective botanical mixture, known as Biocidin®, to provide synergistic immune support for every climate and season.

The probiotics in MegaCidin™, Bacillus subtilis HU58 and Bacillus coagulans (SC-208), are scientifically shown to support a healthy immune system by reducing inflammatory cytokines and producing protective compounds like -defensin.3,4 Additionally, probiotic throat sprays are shown to support healthy oral immunity in children.5

MegaCidin™ also contains an herbal blend known as Biocidin® which includes milk thistle, echinacea, goldenseal, shiitake extract, white willow bark, garlic, grapeseed extract, black walnut, tea tree oil, oregano oil, and several others. Many of these healing plants have been used in traditional medicine for hundreds of years, yet their beneficial qualities have only recently been proven by modern scientific research.

Human clinical trials conducted with Biocidin® show that this botanical mixture can support the immune system in as little as 30 minutes after spraying into the mouth.6 In fact, a single dose of Biocidin® can support the production of one of the most important immunoglobulins, known as secretory IgA, or sIgA.6 This immunoglobulin is found on mucosal surfaces, such as the gut, saliva, and respiratory system, and acts as one of the first lines of defense within the immune system.

Indeed, the number of studies completed on each individual herb in Biocidin®, joined with overwhelming support from the functional medicine community, provides abundant evidence for the use of these herbs in supporting the body’s innate defense system. Combined with the immune-supporting functions of Bacillus subtilis HU58 and Bacillus coagulans SC-208, MegaCidin™ is a preferred, all-natural remedy for healthy immune function. Whether you’re traveling or staying home, just a few sprays a day is all it takes to have a healthier immune system.

1. Brandtzaeg P. Secretory immunity with special reference to the oral cavity. J Oral Microbiol. 2013;5:10.3402/jom.v5i0.20401. 2. Kraan, et al. Buccal and sublingual vaccine delivery. Journal of Controlled Release. 2014;190: 580–592. 3. Baron M. A patented strain of Bacillus coagulans increased immune response to viral challenge. Postgrad Med. 2009;121(2):114–118. 4. Guo M, Wu F, Hao G, et al. Bacillus subtilis Improves Immunity and Disease Resistance in Rabbits. Front Immunol. 2017;8:354. 5. Andaloro C. Bacteriotherapy with Streptococcus salivarius 24SMB and Streptococcus oralis 89a oral spray for children with recurrent streptococcal pharyngotonsillitis: a randomized placebo-controlled clinical study. Eur Arch Otorhinolaryngol. 2019;276(3):879–887.6. Bellar, et al. The Effects of a Botanical Blend on Post-Exercise Mucosal Antimicrobial Proteins J Athl Enhanc. 2018;7:5"